Zhang X, Zhang X, Li X, Lv Y, Zhu Y, Wang J, et al. CEBPA mutation was the most common co-mutation that occurred alongside IKZF1 mutation in AML. IKZF1 aberration conferred poor prognosis in ALL, but only a high burden of IKZF1 mutation predicted poor OS in AML because IKZF1 mutation with VAF < 10% accounted for 35% of all IKZF1 MUT patients, and IKZF1 mutation contributed less to disease than other mutations did in this group of patients. Missense mutation accounted for nearly half of IKZF1 mutations, and it almost affected the DNA-binding domain in AML, while its DNA-binding domain and dimerization domain involvement was relatively balanced in ALL. Unlike in ALL, IKZF1 mutation and deletion were equally dominant in AML. IKZF1 deletion, caused by -7/monosomy 7, was detected in 3.20% of our patients. This may be because patients were of different races or it may be because of differences in sequencing depth. 1H, I).Ĭompared with foreign cohorts (OHSU, 1.35% TCGA, 0.5% TARGET, 4.21%), the frequency of IKZF1 mutation was relatively high (3.83%). IKZF1 mutation combined with SF3B1 mutation conferred extremely poor OS on AML, but the RFS of IKZF1 MUT/ SF3B1 MUT AML patients was unavailable because no patient reached CR (Fig. None of these patients achieved CR at any point during the regimen (Additional file 9: Table S6). IKZF1 WT/ SF3B1 MUT AML patients exhibited a CR rate of 50%, and the therapeutic response was even worse in IKZF1 MUT/ SF3B1 MUT AML. IKZF1 mutation conferred a relatively low CR in the CEBPA WT /non- CEBPA bZIP−inf−MUT group, but not in the CEBPA bZIP−inf−MUT group (Additional file 8: Table S5), and it influenced OS and RFS in the CEBPA WT /non- CEBPA bZIP−inf−MUT group but not in the CEBPA bZIP−inf−MUT group (Additional file 3: Fig S3C, D). In IKZF1 MUT patients, CEBPA bZIP−inf mutation (83.3%) was more common than non- CEBPA bZIP−inf mutation (16.7%). IKZF1 mutation did not influence OS or RFS in CSF3R WT and CSF3R MUT (Additional file 3: Fig S3A, B, Additional file 7: Table S4). The prognostic role of CEBPA bZIP−inf, SF3B1, and CSF3R mutations was revealed in our cohort (Additional file 2: Fig S2). We also performed subgroup survival analysis. IKZF1 mutation exhibited concurrences with CEBPA, SF3B1, and CSF3R mutations, but it was mutually exclusive with NPM1 mutation (Fig. We also analyzed the relationships among IKZF1 mutation and other gene mutations. ( H, I) The prognostic role of combined IKZF1 and SF3B1 mutations on AML was investigated, and the OS ( H) as well as RFS ( I) of AML with different IKZF1 or SF3B1 mutated status are exhibited ( G) The distribution of frequent AML-associated gene mutations in IKZF1 WT and IKZF1 MUT groups, and the count as well as percentage of each gene mutation are shown. ( F) The difference of additional mutations distribution in IKZF1 WT and IKZF1 MUT groups, and the percentage of each gene mutation is exhibited. ( D, E) The influence of IKZF1 mutation burden on the prognosis of AML was studied, and the OS ( D) as well as RFS ( E) of IKZF1 WT, IKZF1 MUT with VAF > 0.20, and IKZF1 MUT with VAF ≤ 0.20 groups are shown. ( B, C) The OS ( B) and RFS ( C) of IKZF1 WT and IKZF1 MUT groups in our AML cohort. The nonsense or frameshift mutation was marked as red, while the missense mutation was marked as blue. ( A) The distribution of IKZF1 mutations, which were identified in our cohort, on the protein. We believe this work improves our knowledge of IKZF1 mutation. In subgroup analysis, our results showed that IKZF1 mutation conferred poor therapeutic response and prognosis for SF3B1-mutated AML (P = 0.0017). IKZF1 mutation showed significant co-occurrences with CEBPA (P 0.20) showed relatively short overall survival period (P = 0.012), and it was an independent factor for the increased risk of death (hazard ratio, 6.101 95% CI 2.278–16.335 P = 0.0003). The baseline characteristics of IKZF1-mutated and wild-type patients were comparable. This condition has a young median age of onset of morbidity (P = 0.032). A total of 26 IKZF1 mutations were found in 20 AML patients (20/522, 3.83%). Herein, we attempt to answer this question in one relatively large cohort covering 522 newly diagnosed AML patients. In a previous work, we described the distribution pattern of IKZF1 mutation in AML, but its clinical impact has remained undefined due to the limited number of cases. Knowledge of the IKZF1 mutation in AML specifically is extremely limited. Genetic heterogeneity poses a great challenge to the understanding and management of acute myeloid leukemia (AML).
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j4nf4b3l/MDMPatcher-Universal - MDM patch should working on iOS 15+. ggerganov/llama.cpp - Port of Facebook's LLaMA model in C/C++.antimatter15/alpaca.cpp - Locally run an Instruction-Tuned Chat-Style LLM.opa334/Dopamine - Dopamine is a semi-untethered permasigned jailbreak for iOS 15.jeremyd2019/winautoconfig - automatic config for a Windows VM in QEMU, for ARM64 and AMD64.AveYo/MediaCreationTool.bat - Universal MCT wrapper script for all Windows 10/11 versions from 1507 to 21H2!.ntdevlabs/tiny11builder - Scripts to build a trimmed-down Windows 11 image.soimort/translate-shell - □ Command-line translator using Google Translate, Bing Translator, Yandex.Translate, etc.rcmaehl/MSEdgeRedirect - A Tool to Redirect News, Search, Widgets, Weather and More to Your Default Browser.kamranahmedse/developer-roadmap - Interactive roadmaps, guides and other educational content to help developers grow in their careers.calc84maniac/tiboyce - A Game Boy emulator for the TI-84 Plus CE and TI-83 Premium CE.0xJonas/TIQuest - Game for the TI-83 plus/TI-84 plus calculators.mytechnotalent/Reverse-Engineering - A FREE comprehensive reverse engineering tutorial covering x86, 圆4, 32-bit ARM & 64-bit ARM architectures.Thanks to everyone who contributes to this, make sure to see contributing.md for contribution instructions! leachim6/hello-world - Hello world in every computer language.uBlockOrigin/uAssets - Resources for uBlock Origin, uMatrix: static filter lists, ready-to-use rulesets, etc.jsassu20/Lenovo-T450-Catalina-OpenCore.There are several forms of tech support scams, all of which aim to trick you into believing that your computer needs to be fixed and you need to pay for technical support services.A curated list of my GitHub stars! Generated by starred. You can also report unsafe websites in Microsoft Edge by selecting Settings and More > Help and Feedback > Report unsafe site when you encounter something suspicious.įor urgent situations, use one of the following options:Īnd consider notifying your local law enforcement agency. Help Microsoft stop scammers, whether they claim to be from Microsoft or not, by reporting tech support scams at: Let them know what happened they'll probably want to cancel and replace your affected cards to prevent the scammers from using them again. Learn how to change your Microsoft account passwordĬall your credit card provider to contest the charges if you've already paid. For more info, see Update Windows.Ĭhange your passwords. To see available updates, select the Start button, then select Settings > Update & Security > Windows Update. Learn how.Īpply all security updates as soon as they are available. Run a full scan with Windows Security to remove any malware. 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The “Arrange Folders On Top” feature might be what some recent converts from Windows are looking for. If you find your eyes are getting tired of the typical white-background black-text combination and yearning for something closer in flavor to Adobe’s darker GUI themes, XtraFinder allows you to switch to a mode called “Light on Dark.” This mode allows you to customize the finder background and text color (defaulting to white text on black background) to help you escape the eye-straining hell of the normal Finder. This is great for doing a quick spot check after a media copy. With the dual window mode you can now easily perform a visual comparison of the contents of multiple folders. When turning on Dual Pane Windows, you will be presented with two different folder locations within one window. This is great for having a number of folders open at once for dragging to and from the browser window.Īside from tabs, this has to be one of the most helpful add-ons that XtraFinder provides. You can easily open a number of folders at once without suffering from a cluttered desktop space. Best of all, as well as being free, the software is easy to use and there is no need to touch the terminal.Īfter installing XtraFinder you will find that your Finder windows will now have the option to add tabs in a single window, much like that of a standard web browser. Well put down that whiskey, because Tran Ky Nam Software now has a free piece of software called “XtraFinder” that makes navigating your sea of files and folders a lot easier. This has made many filmmakers who needed a little extra out of the Finder scream “Damn it Steve, I’m a Filmmaker not a programmer!” and reach for a stiff drink. Sure, you can add a few links to the side and tool bar, but when it came to what they consider “power-user” features such as showing hidden files or folders, you have to access the terminal and enter-in strings of Unix commands. Traditionally, Apple has not allowed much in the way of customization of the Finder. With systems that run FCP7 and Premiere Pro, keeping your projects organized on the Finder level is just as much a part of managing your media as bins and folders are. If you use a Mac for post-production you will find that your Finder is a big part of non-linear editing experience. Haas breaks down the benefits of the “XtraFinder” software from Tran Ky Nam One important feature of Inshot Video Editor is that it also allows you to rotate and flip videos which comes in really handy in certain specific scenarios. There’s also support for stickers, emojis, filters, effects, transitions, color correction, and more. The app also comes with lots of sound effects and supports voice over layering. Another good thing about this app is that even the free version doesn’t show any ads. So whether you are editing your family video, a video for YouTube or for Instagram, you can edit your videos using KineMaster. One of the good things about this app is that it supports landscape, portrait, and square video formats. The app offers professional level editing tools and yet makes it easy to start your video editing journey. KineMaster Video Editor is one of the best iPhone Video editing apps that you can use. One of the best mobile video editing appsĭownload Adobe Premiere Rush from App Store (Free, with in-app purchases) 4. Moreover, Premier Rush is cross-platform and you can use the app across macOS, Windows, iOS, and Android apart from iOS. You can also easily resize videos to different aspect ratios and customize the video thumbnail with this app. There are some other apps, let’s take a look.For those who want the flexibility to manage multiple video tracks, Premiere Rush’s timeline view offers a split view and picture-in-picture mode to help you efficiently edit videos. Now you feel at ease after reading how to combine videos on iPhone by using an app. Now your video is saved into your gallery.After whole settings Save the video by selecting the option of Save in the upper right corner and waiting for seconds.In Featured, tap on “Extract Audio From Video”.If you want to extract the sound then click on “Music” and choose “Track”.Select the multiple clips and mark “Tick”.On the above choice the option “Video” if you want to add video clips otherwise choose “All” for video and photos.In creating a new choose the option of “Video”.This app allows you to use it for free and if you want some advanced features then you should buy Inshot pro. Using this app you can trim your video, cut your clips, add filters and transitions, make a video with photos, set the background, set the slow and fast speed, remove background sounds and add stickers. This app allows you to extract audio from different videos. You can add multiple video clips and also set your favorite songs. How to join two vertical videos by Inshot? Inshot is a very unique app for editing and joining clips. Yes, you can save your live photo as a video on your iPhone. You can just work on split clips in iMovie and rejoin it. Why can’t I join clips in iMovie? If your join clip option is not working then it means you are unable to merge clips independently. If your iMovie doesn’t allow you to join clips then you can use different apps rather than iMovie. How to merge vertical videos without iMovie? There are many options to merge video clips. Now let’s see how to combine videos on iPhone with other methods. Save your video in a gallery or send it to your friends.Now preview your video and Click on done after changes. You can also cut the video point if you want. You can make different changes to add filters and transitions.After selection now tap on Create video.If you want to merge then again select video and tap on the checkbox and repeat this process to combine more videos.Select the video and click on the checkbox for an edit of one video.Select the desired folder by clicking on “All” after opening the video page.Click on “Movie” when a new screen opens. All of this is achieved via My Friend Pedro‘s intuitive twin-stick control system, allowing for lock-ons, split-firing, and quick access to your growing cache of weapons.Īside from several unique sequences and boss battles (which I won’t spoil here), that is, in essence, the entire game. When the returning fire gets a little too thick, a quick twirl, forward roll, and even nearby furniture can give you a second of breathing space before you continue on your quest to fire and forget. At the click of a button, players can slow the action right down, allowing for accurate placement of individual shots, a stylish reload, or just an extra second to plan the next move from your second-story suicide dive. The environment is also on your side, with petrol cans, pressure canisters, severed limbs, and even skateboards and frying pans all ready to aid you in battle, whether through room-clearing explosions or smug shots ricocheted into those hard-to-reach corners.Īlso helping players out in a pinch is that mainstay of the early ’00s: Bullet Time. Combining your murderthon with flips, wall jumps, cartwheels, window smashes, and rope swings increases your style points, while a multiplier awards players who move slickly from shootout to shootout, nimbly avoiding getting bogged down in scenery and viscera. The real points, however, are racked up by cutting loose and getting your John Woo on.Īs you may have gathered from My Friend Pedro‘s marketing, balletic gun battles are the key to high scores. At the end of each stage, bonuses are awarded for speed, one-life runs, and clearing the entire stage of enemies. With a deep control engine built almost entirely on platform traversal and gunplay, the player must combine our hero’s acrobatic and sharp-shooting skills in order to reach the end of each stage quickly, efficiently, and hopefully not resembling Swiss cheese. The aim of My Friend Pedro is simply to complete each stage as quickly and as smoothly as possible. Guided by his banana buddy, the protagonist then ventures through a series of equally odd locations, stocking up on an arsenal of automatic weaponry and throwing endless lead in harm’s way. Convinced that his life may be in danger, our protagonist grabs an errant handgun and proceeds to break out of their meat-locker of a cell. A young masked man awakens in a dingy basement, bought around by a somewhat irreverent talking banana. The narrative of My Friend Pedro is simple, yet frightening. In that sense, they are a callback to the arcade classics of yore, where the goal wasn’t necessarily to finish the game, or see the ending, but simply to “get better,” with the ultimate prize being the satisfaction of smashing your own high scores and, hopefully, those of your local arcade bully too. These are games intended to be played over and over again, with the player constantly pushing their abilities and topping their own records. This new title from Swedish indie outfit DeadToast Entertainment falls under the highly-replayable score-attack genre, of which publisher Devolver Digital is very proud (think High Hell, Ape Out, or Ruiner ). My Friend Pedro is a ballistic game of skill, timing, reflexes, and, surprisingly, efficient time management. 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It’s amazing what you can tell about a person by the way they answer and respond to a crank caller, observations the creators of the show brilliantly incorporate into the program’s aesthetic (one particularly hard-assed crankee has a picture of Ronald Reagan next to his phone).Įvery week, the creators miraculously tap into the social problems that separate the caller and the person being called, and every response is a reminder of the way we connect (or don’t) with one another. Some of the cranks may be mean-spirited, but I can’t think of another comedy on television this concerned with testing people’s tolerance levels and compassion for others. If you can tell a lot about a person by the way they answer the phone, then I wonder what you can tell about a person by what sketches they prefer. My favorite cranks from the show’s first season (in no particular order): the perpetually horny Cammie (Lisa Kushell) toys with a sad and lonely computer nerd after one of her drives goes bust Gladys (Wanda Sykes) accuses a mechanic of having “pinched a loaf” inside her car “Batman’s Nemesis” (Jordan Rubin) asks a clueless New York City operator for the address to Batman’s lair Special Ed (Jim Florentine, a master of comedic timing) calls a computer technician to report that he got mail on his computer a woman at a beauty parlor secretly tells Hadassah (Sarah Silverman) that she can cure her case of the crabs with plain yogurt, advice the cranker interprets as a “a battle of good and evil in my vagina” and Hadassah a phone call to a freaky Oprah fan to leak information about the abuses she and her co-workers incur at the hands of her celebrity boss. In the first season, the creators were clearly trying to figure out the best way to piece the show’s skits together. Curiously, the lame musical performances (from Tenacious D and Ween) that physically bring many of the puppets together less successfully evoke a sense of community in Yankerville than the regular scenic transitions and Laugh In-style non sequiturs, from the Sesame Street potshots to the “Confucius Says” jokes. MTV Entertainment Studios (2021–present)Ĭrank Yankers is an American television show produced by Adam Carolla, Jimmy Kimmel and Daniel Kellison.Though some digital compression is noticeable in parts, the show’s puppets look great-their colors are rich and contrast is top-notch-and sound almost as good (if the people getting cranked don’t sound as good as the crankers, that’s to be expected). It features actual crank calls made by show regulars and celebrity guests, while re-enacted onscreen by puppets for a visual aid that shows the viewer what is happening in the call. The show premiered on June 2, 2002, on Comedy Central. 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